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PIQASO: A rigid phantom for comprehensive end-to-end evaluation of online adaptive radiotherapy systems

There is currently no radiotherapy phantom capable of quantitatively assessing all components of an online adaptive radiotherapy (online ART) system in a comprehensive end-to-end test.Represented here is a novel, rigid phantom that can simultaneously evaluate an online ART system's image acquisition, deformable image registration, contour propagation, plan re-optimization, dose calculation, and beam delivery in a single process that is robust, quantitative, and convenient.


Licensing Contact

Masood Machingal

615.343.3548

Non-Invasive Bacterial Identification for Acute Otitis Media using Raman Spectroscopy

Vanderbilt researchers have developed an optical-based method for real-time characterization of middle ear fluid in order to diagnose acute otitis media, also knows as a middle ear infection. The present technique allows for quick detection and identification of bacteria and can also be applied to other biological fluids in vivo.


Licensing Contact

Masood Machingal

615.343.3548

Self-Decoupled RF Coils for Optimized Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is one of the most important and versatile tools in the repertoire of diagnostics and medical imaging. Vanderbilt researchers have developed a novel, geometry independent, self-decoupling radiofrequency (RF) coil design that will allow MRI machines to generate images at a faster rate and with greater image quality.


Licensing Contact

Brennen Carr

615.343.2430

Head Motion Correction with Soft Pressure Pad for MRI Scans

Vanderbilt University researchers have developed a novel soft pressure sensing pad to track head motion during MRI to improve diagnostic image quality and reduce erroneous artifacts.


Licensing Contact

Chris Harris

615.343.4433

Speculum-Free Diagnostic Probe for Optical Assessment of the Cervix

A new approach for obtaining less invasive optical measurements of the cervix has been developed that does not require the use of a speculum exam. This technology can visualize the cervix in vivo to find unique biomarkers that indicate various conditions such as preterm labor, cancer, human papillomavirus (HPV), and dysplasia.


Licensing Contact

Masood Machingal

615.343.3548

A Method to Obtain Uniform Radio Frequency Fields in the Body for High Field MRI

Researchers at Vanderbilt have created a new approach to produce uniform radio frequency (RF) fields in the body during high field magnetic resonance imaging (MRI). Existing high field MRI machines create non-uniform RF fields that lead to non-uniform sensitivity in the generated images, also referred to as "hot" and "cold" spots. These local variations interfere with the tissue contrast of the images that radiologists depend upon to make accurate diagnoses. By generating uniform RF fields in the body, this technology provides the benefits of high field MRI without the non-uniform RF fields.


Licensing Contact

Chris Harris

615.343.4433
Medical Imaging

Enhanced Optical Imaging for the Treatment of Retinal Disease

Vanderbilt researchers have developed a system for enhancing the imaging capabilities of optical coherence tomography (OCT), a tool commonly used to monitor and treat patients with retinal disease. The image resolution of OCT, however, is intrinsically limited. Ideally, a contrast agent could be used to highlight specific parts of the retina within the image, but dye alone is largely ineffective because of the way OCT generates the image. Photothermal heating solves this problem by creating local zones of tissue expansion which can be distinctly detected by OCT. Photothermal-OCT is safe, effective, and enhances the imaging power of a tool widely used by opticians.


Licensing Contact

Philip Swaney

615.322.1067
Medical Imaging

Advanced Method for Data Corrections in Organ Deformation

A group of Vanderbilt University researchers have developed a solution that will correct for the mis-registration of image data in image-guided surgery. The solution uses software to correct for any mis-registration that is caused by the presence of intraoperative deformations. This invention helps to improve the performance and capabilities of image-guided surgery.


Licensing Contact

Philip Swaney

615.322.1067
Medical Imaging

Latent Image-Derived Features for Prognostic Modeling

Researchers at Vanderbilt have developed a system to estimate prognostic metrics such as the length of a hospital stay, recovery status at discharge, and overall health at discharge, using only baseline imaging and clinical information gathered early in the hospital admission process. This system can assist with medical group operations and planning, it can help to educate families and patients regarding prognosis, and can be used to automatically stage patients for clinical trials.


Licensing Contact

Chris Harris

615.343.4433
Medical Imaging

Real-time Detection of Position and Orientation of Wireless Endoscopy Capsule using Magnetic coupling

Vanderbilt researchers have developed a new system to detect the position, orientation, and pressure exerted on surrounding tissues of a wireless capsule endoscopy device.  Magnetic coupling is one of the few physical phenomena capable of transmitting actuation forces across a physical barrier.  Magnetic manipulation has the potential to make surgery less invasive, by allowing untethered miniature devices to enter the body through natural orifices or tiny incisions, and then maneuver with minimal disruption to healthy tissue.  In order to accomplish this goal, the pose (position and orientation) of the medical device must be available in real time.


Licensing Contact

Masood Machingal

615.343.3548