Vanderbilt researchers have developed a thermoresponsive filament material for use in 3D printing that can be readily dissolved via cooling. This material has use in a multitude of different applications. One potential application is lost-wax casting for tissue engineering. The present material enables the user to print an intricate vascular structure, embed the structure in an engineered tissue construct, and then dissolve the printed structure to create a hollow vascular network embedded within the tissue construct.