Browse Technologies

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Engineering the Sodium/Iodide Symporter for Enhanced Targeted Internal Radiotherapy

The Sodium/Iodide symporter (NIS) is a critical protein that facilitates the active transport of iodide into thyroid cells, essential for synthesizing thyroid hormones. Recent advancements in engineering NIS variants aim to selectively transport oxyanions, offering innovative therapeutic strategies for cancer treatment in the thyroid and elsewhere while minimizing side effects.


Licensing Contact

Carlos Detres Roman

615.343.2430
Therapeutics
Genomic Therapy

A Novel, Human-Derived HER2 Antibody for Cancer Therapeutics and Diagnostics

Vanderbilt researchers have discovered a human-derived antibody that recognizes HER2, a protein overexpressed in various cancers. These antibodies offer potential novel cancer therapeutics and diagnostic tools with improved immunological compatibility compared to humanized antibody alternatives.


Licensing Contact

Cameron Sargent

615.322.5907
Antibody
Antibody

Novel Curcumin Derivatives with Enhanced Anti-Inflammatory Properties

Vanderbilt researchershave identified two novel curcumin derivative compounds withenhanced anti-inflammatory activity and improvedtherapeutic potential.


Licensing Contact

Carlos Detres Roman

615.343.2430

Genetic engineering approach for enhancing recombinant protein production by mammalian cells

Vanderbilt researchers have developed a novel approach to enhance recombinant protein production in mammalian cell culture systems by overexpressing specific metabolic proteins in these cells to achieve higher monoclonal antibody titers and increased cell-specific productivity compared to conventional expression systems.


Licensing Contact

Cameron Sargent

615.322.5907

Targeting PD-1H to treat Acute Myeloid Leukemia (AML)

Despite the success of immune checkpoint inhibitors (ICI) like anti-PD-1 in treating other cancers, these therapeutics have not been demonstrated to effectively treat acute myeloid leukemia (AML). Vanderbilt researchers have identified PD-1H as a potential target for treating AML, opening the door for effective therapy using an ICI molecule.


Licensing Contact

Cameron Sargent

615.322.5907

Inventors

Tae Kon Kim
Therapeutics
Oncology

Novel Growth Factor for Liver Regeneration

Liver transplantation is the only cure for end-stage liver disease, but donor organ scarcity limits access for millions. Split liver transplantation could help bridge this gap, but the regeneration of partial organs is critical to broadlyimplementing this approach. Vanderbilt University researchers have identified a growth factor that promotes liver growth that could be used to improve patient outcomes and increase accessibility to liver transplantation.


Licensing Contact

Cameron Sargent

615.322.5907
Surgery
Protein/Peptide
Protein/Peptide

Anti-inflammatory microparticles for sustained ocular drug delivery

Vanderbilt researchers have developed an injectable drug delivery vehicle using microparticles (MPs) that not only provide sustained cargo delivery over extended time but also play a therapeutic role themselves in reducing inflammation. This drug delivery platform can be used in treating ocular diseases such as glaucoma and traumatic optic neuropathy, as well as other inflammatory diseases throughout the body like peripheral arterial disease and osteoarthritis.


Licensing Contact

Taylor Jordan

615.936.7505

Targeted photodynamic therapy for S. aureus infections

Vanderbilt researchers have developed a combination photodynamic therapy (PDT) for targeting MRSA infections in skin that is not only effective but also HIGHLY SPECIFIC and LESS SUSCEPTIBLE TO RESISTANCE, adding a much needed therapy to our quickly depleting arsenal against this pathogen.


Licensing Contact

Cameron Sargent

615.322.5907

Targeted light-based therapy for acne

Vanderbilt researchers have developed a photodynamic therapy (PDT) for effectively and specifically treating acne, the most common skin condition.


Licensing Contact

Cameron Sargent

615.322.5907
Therapeutics
Small Molecule

Oral administration of levocarnitine for treating Sjögren's Syndrome-associated dry eye

Sjögren's syndrome (SjS) is a common and debilitating autoimmune disease, causing dry eye symptoms ranging from discomfort to dysfunction. Vanderbilt researchers have identified orally administered levocarnitine as a novel potential therapeutic for treating this condition.


Licensing Contact

Mike Villalobos

615.322.6751
Opthamology