Browse Technologies

Displaying 1 - 10 of 20

Non-Invasive Skin Cancer Detection using Raman Spectroscopy-OCT System (Portfolio)

Vanderbilt University researchers have designed a system for non-invasive discrimination between normal and cancerous skin lesions. The system combines the depth-resolving capabilities of OCT technique with Raman Spectroscopy's specificity of molecular chemistry. By linking both imagining techniques into a single detector arm, the complexity, cost, and size of previously reported RS-OCT instruments have been significantly improved. The combined instrument is capable of acquiring data sets that allow for more thorough assessment of a sample than existing optical techniques.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Anita Mahadevan-Jansen, David Dickensheets, Chetan Patil, Tom van Leeuwen, Chad Lieber, Jereon Kalkman
Category:
Diagnostics Medical Devices Medical Imaging

Adaptive PCR: A PCR control system to overcome challenging conditions

A PCR control system to overcome challenging conditions. By directly monitoring the hybridization of fluorescently labelled L-DNA mimics of the template DNA strands and primers, it is possible to improve the efficiency of PCR in challenging conditions. This approach eliminates some of the sample preparation and trial and error that would otherwise be required for difficult sample types such as urine or other samples that contain high levels of salts.  In addition, this approach enables on-demand PCR in most any environment.

Licensing Contact

Karen Rufus

615.322.4295

Inventors

Frederick Haselton, Elliott Dawson, Nicholas Adams, Steve Simmons
Category:
Diagnostics Medical Devices
Field of Use:
Research Reagent

Low-cost, Normally Closed Microfluidic Valve

Vanderbilt researchers have developed a normally closed valve that is able to provide selective movement of small fluid quantities in a microfluidic device. The present microfluidic valve can be actuated using a simple rotating drivehead and mechanical support, greatly simplifying the valve design.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

John Wikswo, Jr., Dmitry Markov, Lisa McCawley, John McLean, David Cliffel, Ronald Reiserer, Philip Samson, Frank III Block, Jennifer McKenzie, William Matloff, William Tidwell, Joseph Scherrer, Erik Werner, Frank Jr. Block
Category:
Diagnostics Microfluidics

Breast Tumor Margin Detection System Using Spatially Offset Raman Spectroscopy

Vanderbilt University researchers have developed a technology that uses spatially offset Raman spectroscopy to obtain depth-resolved information from the margins of tumors. This helps to determine positive or negative tumor margins in applications such as breast lumpectomy, and the technology is currently being investigated for breast cancer margin detection.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Anita Mahadevan-Jansen, Quyen Nguyen, Matthew Keller, Xiaohong Bi, Mark Kelley, Zain Gowani, Ginger Holt, Isaac Pence, John Nguyen
Category:
Diagnostics Medical Devices Medical Imaging

Cutting-Edge Brain Age Estimation from Diffusion MRI

Vanderbilt researchers have developed a novel brain age estimation framework that leverages diffusion MRI to capture microstructural changes associated with aging. This innovative approach outperforms conventional T1-weighted MRI methods by focusing specifically on subtle brain changes, providing a powerful tool for early detection of neurodegenerative diseases and enabling earlier clinical intervention.

Licensing Contact

Virinchi Juttukonda

615.343.2430

Inventors

Chenyu Gao, Bennett Landman, Michael Kim
Category:
Diagnostics Medical Imaging

A Novel Organs-On-Chip Platform

Vanderbilt researchers have created a new multi-organs-on-chip platform that comprises Perfusion Control systems, MicroFormulators, and MicroClinical Analyzers connected via fluidic networks. The real-time combination of multiple different solutions to create customized perfusion media and the analysis of the effluents from each well are both controlled by the intelligent use of a computer-operated system of pumps and valves. This permits, for the first time, a compact, low-cost system for creating a time-dependent drug dosage profile in a tissue system inside each well.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

John Wikswo, Jr., Frank III Block, Dmitry Markov, Philip Samson, David Schaffer, Ronald Reiserer
Category:
Diagnostics Medical Devices Microfluidics Research Tools

Assessment of Right Ventricular Function Using Contrast Echocardiography

Vanderbilt Medical Center researchers have developed a non-invasive and reproducible method of assessing right-ventricular function using contrast-echocardiography. The right-ventricular transit time (RVTT) measures the time needed for echocardiographic contrast to travel from the RV to the bifurcation of the main pulmonary artery. Coupled with the pulmonary transit time (PTT), the time needed for contrast to traverse the entire pulmonary circulation, RVTT is part of a family of diagnostic parameters that can report on RV-specific performance as well as the RV's function relative to that of the pulmonary circuit as a whole.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Ken Monahan, Evan Brittain, Steven Boronyak, William Merryman
Category:
Diagnostics Medical Imaging

Advanced Ultrasound Imaging for Kidney Stone Detection

The standard for kidney stone detection is through the use of computed tomography (CT). However, CT is expensive and delivers harmful ionizing radiation into the body. Ultrasound would be the ideal way to detect kidney stones except that it performs poorly in detecting and accurately sizing stones. Vanderbilt researchers inventors have developed a technique that is able to separate hard, mineralized material (i.e kidney stones) from soft tissue in a way that is both cheaper and safer than CT and performs better than conventional ultrasound imaging.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Brett Byram, Ryan Hsi, Jaime Tierney
Category:
Diagnostics Medical Imaging
Field of Use:
Genitourinary

Molecular Image Fusion: Cross-Modality Modeling and Prediction Software for Molecular Imaging

A research team at Vanderbilt University Mass Spectrometry Research Center has developed the Molecular Image Fusion software system, that by fusing spatial correspondence between histology and imaging mass spectrometry (IMS) measurements and cross-modality modeling, can predict ion distributions in tissue at spatial resolutions that exceed their acquisition resolution. The prediction resolution can even exceed the highest spatial resolution at which IMS can be physically measured. This software has been successfully tested on different IMS datasets and can be extended to other imaging modalities like MRI, PET, CT, profilometry, ion mobility spectroscopy, and different forms of microscopy.

Licensing Contact

Karen Rufus

615.322.4295

Inventors

Richard Caprioli, Raf Van de Plas
Category:
Diagnostics Medical Imaging Research Tools
Research Tool Type:
Mass Spectrometry Tools

Bioresorbable RF Coils for Post-Surgical Monitoring by MRI

Vanderbilt researchers have developed bioresorbable RF coils to improve the signal-to-noise ratio (SNR) for use in post-surgical monitoring.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Mark Does, John Rogers
Category:
Diagnostics Medical Imaging