Browse Technologies

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Speculum-Free Diagnostic Probe for Optical Assessment of the Cervix

A new approach for obtaining less invasive optical measurements of the cervix has been developed that does not require the use of a speculum exam. This technology can visualize the cervix in vivo to find unique biomarkers that indicate various conditions such as preterm labor, cancer, human papillomavirus (HPV), and dysplasia.


Licensing Contact

Masood Machingal
masood.machingal@vanderbilt.edu
615.343.3548

Rotary Planar Peristaltic Micropump (RPPM) and Rotary Planar Valve (RPV) for Microfluidic Systems

A Vanderbilt University research team led by Professor John Wikswo has developed low-cost, small-volume, metering peristaltic micropumps and microvalves. These pumps and valves can be used either as stand-alone devices incorporated into microfluidic subsystems, or as readily customized components for research or miniaturized point-of-care instruments, Lab-on-a-Chip devices, and disposable fluid delivery cartridges.


Licensing Contact

Masood Machingal
masood.machingal@vanderbilt.edu
615.343.3548

Tentacle-Like Robots to Access Tight Spaces in Manufacturing and Medical Applications

Vanderbilt researchers have developed a novel method for enabling tentacle-like robots to reach into tight spaces in manufacturing or medical applications. This is useful for industrial inspection tasks, assembly of products like airplane wings with complex geometry, or making medical endoscopes reach places in the body they cannot reach today. The new invention involves routing actuation wires along a flexible arm through curved paths along the robot


Licensing Contact

Chris Harris
chris.harris@vanderbilt.edu
615.343.4433
Medical Devices

Lickometer: Instrument for measuring rodent drinking behavior

Researchers at Vanderbilt University designed an instrument capable of higher accuracy and analyzing lick microstructure compared to current available models. This device is compatible with classic ventilated home cages, making it easy to build and use with an intuitive touchscreen graphical user interface. The system tracks two-bottle choice licking behavior in up to 18 rodent cages, or 36 single bottles, on a minute-to-minute timescale controlled by a single Arduino microcontroller. Ultimately, the system measures drinking preference over time and changes in bout microstructure, with undisturbed recordings lasting up to 7 days.


Licensing Contact

Greg Pawel
gregory.pawel@vanderbilt.edu
615.343.0996

Oral administration of levocarnitine for treating Sjögren's Syndrome-associated dry eye

Sjögren's syndrome (SjS) is a common and debilitating autoimmune disease, causing dry eye symptoms ranging from discomfort to dysfunction. Vanderbilt researchers have identified orally administered levocarnitine as a novel potential therapeutic for treating this condition.


Licensing Contact

Mike Villalobos
mike.villalobos@vanderbilt.edu
615.322.6751
Opthamology

Small Molecule-GIRK Potassium Channel Modulators That Are Anxiolytic Therapeutics

The G-protein activated, inward-rectifying potassium (K+) channels, "GIRKs", are a family of ion channels that has been the focus of intense research interest for nearly two decades. GIRK has been shown to play important roles in the pathophysiology of diseases such as anxiety, epilepsy, Down's syndrome, pain perception and drug addiction. Here scientists at Vanderbilt developed the first truly potent, effective, and selective GIRK activator, ML297 (VU0456810) and demonstrated that ML297 is active in animal models of epilepsy. While the group is using ML297 to continue to explore the therapeutic benefits of GIRK modulation, they are continuing to develop more selective and druggable GIRK inhibitors from different scaffolds.


Licensing Contact

Cameron Sargent
cameron.sargent@vanderbilt.edu
615.322.5907
Therapeutics
Analgesic
Small Molecule

Diagnostics Management Team

The sheer volume of medical information available to physicians today is overwhelming. Diagnostic Management Team provides a concise, accurate method for ordering the correct diagnostic tests every time, and it returns the results in a uniform report format, easily read by the physician. This has already been launched within Vanderbilt University, with a high adoption rate amongst physicians and has already shown significant savings.


Licensing Contact

Chris Harris
chris.harris@vanderbilt.edu
615.343.4433

Inventors

Mary Zutter
Oncology

Use of Fluid Shear Stress Treatment to Enhance T Cell Activation

Researchers at Vanderbilt University have developed a technique to enhance immune cell activation by exposing cells to mechanical force while culturing. Proof-of-concept data indicate that activating immune cells with this method may improve therapeutic efficacy and reduce manufacturing expenses, making powerful CAR T cell therapies more accessible to patients in need.


Licensing Contact

Cameron Sargent
cameron.sargent@vanderbilt.edu
615.322.5907

Improved Biomanufacturing Using Biological Clock Control for High Yield/Low Cost Bioproduct

A team of researchers at Vanderbilt University has developed a method of manipulating the circadian clock of cyanobacteria. This biological manipulation is used to increase gene expression in target genes that produce biofuel and high-value bioproducts, such as pharmaceuticals and cosmetics from precursor-expressing genes. Altering the circadian rhythm in the bacteria provides an improved approach to bioproduct development on a large scale using sunlight as a zero--cost energy solution.


Licensing Contact

Masood Machingal
masood.machingal@vanderbilt.edu
615.343.3548

A Method to Obtain Uniform Radio Frequency Fields in the Body for High Field MRI

Researchers at Vanderbilt have created a new approach to produce uniform radio frequency (RF) fields in the body during high field magnetic resonance imaging (MRI). Existing high field MRI machines create non-uniform RF fields that lead to non-uniform sensitivity in the generated images, also referred to as "hot" and "cold" spots. These local variations interfere with the tissue contrast of the images that radiologists depend upon to make accurate diagnoses. By generating uniform RF fields in the body, this technology provides the benefits of high field MRI without the non-uniform RF fields.


Licensing Contact

Chris Harris
chris.harris@vanderbilt.edu
615.343.4433
Medical Imaging