cancer immunotherapy

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Encephalitis identified as rare toxicity of immunotherapy treatment

After a cancer patient receiving an immunotherapy developed encephalitis and died 18 months into treatment, researchers at Vanderbilt-Ingram Cancer Center (VICC) investigated why the complication occurred, performing a molecular analysis of the disease’s pathology and mining data to determine the incidence of similar occurrences.

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Research cancer immunotherapy checkpoint inhibitors Department of Medicine douglas johnson encephalitis Justin Balko Nature Medicine Vanderbilt Ingram Cancer Center

Discovery points to new cancer immunotherapy option

An international team involving Vanderbilt researchers has discovered that a new “checkpoint” protein on immune system cells is active in tumors, and that blocking it — in combination with other treatments — is a successful therapeutic approach in mouse models of cancer.

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Amy and Barry Baker Lab cancer immunotherapy Cancer Research checkpoint inhibitors department of otolaryngology Flow Cytometry Shared Resource immune system immunotherapy t cell Vanderbilt Ingram Cancer Center Vanderbilt Institute for Infection Immunology and Inflammation Young Kim

Nanoparticle targets tumor-infiltrating immune cells, flips switch telling them to fight

New research builds on Nobel-winning immune checkpoint blockade work

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Engineering and Technology bioengineering cancer immunotherapy Research immune checkpoint blockade John T. Wilson melanoma nanoparticles

Immunotherapies linked to specific heart complications

Immunotherapies linked to specific heart complications

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adverse drug reactions cancer immunotherapy cancer checkpoint inhibitors Department of Medicine douglas johnson immunotherapy James C. Bradford Jr. Melanoma Fund Javid Moslehi NCI NIH The Lancet Oncology Vanderbilt Cardio-Oncology Vanderbilt Ingram Cancer Center

Team’s findings show glutamine metabolism affects T cell signaling

Team’s findings show glutamine metabolism affects T cell signaling

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Autoimmune disease cancer immunotherapy CAR T Therapy Cell Cell Metabolism center for immunobiology glutamine immunotherapy inflammation jeffrey rathmell NCI NHLBI NIH. Pathology microbiology and immunology t cell

Novel, ‘multiplexed’ diagnosis may better identify candidates for cancer immunotherapy

Novel, ‘multiplexed’ diagnosis may better identify candidates for cancer immunotherapy

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Anita Mahadevan-Jansen breast cancer cancer immunotherapy gold nanoparticles Raman spectra Rizia Bardhan chemical and biomolecular engineering Research