American Heart Association

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Cellular engines of wound repair have distinct roles

Cellular engines of wound repair have distinct roles

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Research American Heart Association fibroblast National Blood Foundation Nature Communications Pampee Young pathology microbiology and immunology Sarika Saraswati wound repair

Signals from the “conveyor belt”

Cellular signaling pathways involved in everything from the proliferation of fatty tissue to the death of neurons in the brain are tightly regulated by “cascades” of sequentially activated enzymes, MAP kinases.

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Health and Medicine Research American Heart Association Basic Sciences cell signaling department of biochemistry Department of Biomedical Informatics Department of Pharmacology national science foundation Tina Iverson Vsevolod Gurevich

Vanderbilt study suggests way to prevent rare lung disease

Vanderbilt study suggests way to prevent rare lung disease

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American Heart Association biomedical engineering David Merryman Department of Pediatrics Department of Pharmacology NIH NHLBI circulation research

Stretch, inflammation and hypertension

Monocytes are known to play an important role in hypertension, although the exact mechanism remains unclear. It is hypothesized that a potential source of monocyte activation originates from its interaction with the vascular endothelium.

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Health Medicine Research American Heart Association Cardiovascular David Harrison Department of Medicine Division of Clinical Pharmacology hypertension immune response NHLBI NIH

Unleashing TIGER on small RNAs

Efforts to explore the landscape of small RNAs (sRNAs) — short RNA molecules that are poorly understood — often use high-throughput sequencing (sRNA-seq). These efforts are hampered by a lack of tools to identify, quantify and analyze all the different sRNAs in sRNA-seq datasets.

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American Heart Association Basic Sciences Department of Medicine Journal of Extracellular Vesicles Kasey Vickers Molecular Physiology & Biophysics NCATS NCI NHLBI NIDDK NIGMS NIH RNA

Scavengers “protect” HDL

High-density lipoprotein (HDL) is widely thought to protect against the development of atherosclerosis, yet drugs that raise levels of HDL cholesterol (HDL-C) have failed to reduce the risk of heart disease.

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AHA American Heart Association atherosclerosis Basic Sciences cholesterol Department of Pharmacology HDL Journal of Biological Chemistry NHLBI NIH Research Sean Davies