department of biochemistry

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James Crowe, Neil Osheroff honored by AAMC

James Crowe, Neil Osheroff honored by AAMC

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Health and Medicine Research antibodies association of american medical colleges department of biochemistry Department of Medicine Department of Pediatrics James Crowe medical education Neil Osheroff pathology microbiology and immunology

Study examines HIV drug’s potential to treat Alzheimer’s

A drug used to treat and prevent HIV/AIDS is showing promise as a potential therapy for Alzheimer’s disease, and Vanderbilt University biochemist F. Peter Guengerich, PhD, is aiding efforts to make this approach to improving memory and cognitive function even better.

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Health and Medicine Alzheimer's Disease department of biochemistry HIV/AIDS Journal of Medicinal Chemistry memory Peter Guengerich Research

Imaging host-pathogen battle for metal

Bacterial pathogens require nutrient metals to survive and cause disease, and hosts try to protect themselves by hiding metals away — a process called “nutritional immunity.” Bacteria have evolved multiple strategies for getting the metals they need, including the secretion of small molecule metal-binding “sponges” called siderophores.

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Research Basic Sciences department of biochemistry Eric Skaar imaging mass spectrometry infectious disease Mass Spectrometry Research Center pathology microbiology and immunology Richard Caprioli staph Staphylococcus aureus Vanderbilt Institute for Infection Immunology and Inflammation VI4

A catalog of DNA replication proteins

A catalog of DNA replication proteins

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Research Basic Sciences breast cancer research foundation david cortez department of biochemistry DNA Replication Genome Maintenance Research Program Vanderbilt Ingram Cancer Center

A critical factor for wound healing

Using mouse skin as a model system, J. Scott Beeler, Jennifer Pietenpol, PhD, and colleagues found that p73 is required for the timely healing of cutaneous wounds. In normal tissue, p73 expression increased in response to wounding, whereas p73 deficiency resulted in delayed wound healing, they reported in the journal PLOS ONE.

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Research Basic Sciences department of biochemistry DNA Damage Jennifer Pietenpol p53 skin Vanderbilt Ingram Cancer Center wound

Steroid binding to metabolic enzyme

The human cytochrome P450 enzymes are responsible for metabolizing a variety of substances — from lipids (fats) and steroid hormones to drugs and toxic chemicals.

One such enzyme, P450 17A1, generates androstenedione and dehydroepiandrosterone (DHEA), involved in the production of sex hormones. How the enzyme binds to its substrates has remained a mystery until now.

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Research Basic Sciences department of biochemistry enzyme Fred guengerich Journal of Biological Chemistry metabolism steroids

Cancer’s SOS

Cancer’s SOS - New Research From Stephen Fesik and Colleagues

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Research ACS Chemical Biology Basic Sciences Drug Discovery department of biochemistry Department of Chemistry Department of Pharmacology g protein Lustgarten Foundation Stephen Fesik

Novel DNA repair mechanism preserves genome integrity: study

Novel DNA repair mechanism preserves genome integrity: The new mechanism, which is initiated by a protein called HMCES, was reported in the journal Cell.

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Basic Sciences breast cancer research foundation VICC cells david cortez department of biochemistry DNA Damage DNA REPAIR DNA Replication gene mutation susan g. komen foundation Vanderbilt Ingram Cancer Center

The yin and yang of cell signaling

The yin and yang of cell signaling

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Health and Medicine Research Basic Sciences cancer cell signaling department of biochemistry inflammation Journal of Lipid Research Lawrence Marnett neurodegeneration

Signals from the “conveyor belt”

Cellular signaling pathways involved in everything from the proliferation of fatty tissue to the death of neurons in the brain are tightly regulated by “cascades” of sequentially activated enzymes, MAP kinases.

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Health and Medicine Research American Heart Association Basic Sciences cell signaling department of biochemistry Department of Biomedical Informatics Department of Pharmacology national science foundation Tina Iverson Vsevolod Gurevich