Browse Technologies

Displaying 21 - 30 of 184


New antibiotics against new targets in multi-drug resistant microorganisms

New everninomicin antibiotics including a potent bifunctional antibiotic natural product targeting two different and distant ribosomal sites are under development and can be readily produced using synthetic biology. Developing resistance to this bidentate antibiotic should be very difficult for pathogenic microorganisms.


Licensing Contact

Mike Villalobos
mike.villalobos@vanderbilt.edu
615.322.6751
Therapeutics
Infectious Disease
Small Molecule

Long-Lasting and Self-Sustaining Cell Therapy System

Researchers at Vanderbilt have created a novel drug delivery system using two distinct T-cell populations that interact to promote engraftment and persistence in pre-clinical models, increasing the efficacy of T-cell therapies. Furthermore, "booster" treatments can be administered months after the first dose to produce an expansion of antigen specific T cells. These advantages result in longer-term therapeutic efficacy and could reduce the number of treatments required. This system also represents a viable self-renewing platform for the delivery of biologic drugs in patients who would otherwise require frequent administration.


Licensing Contact

Cameron Sargent
cameron.sargent@vanderbilt.edu
615.322.5907

Novel anti-platelet therapy for treatment of thrombosis, cardiovascular disease, and cerebrovascular injury

One of the leading causes of deaths in developed countries is related to thromboembolism. PAR-4 (protease activated receptor-4) is one of two receptors on the human platelet that respond to thrombin, the central enzyme of coagulation.  Researchers here at Vanderbilt University have developed novel antagonists of PAR-4 that could be beneficial for patients allowing for normal hemostasis during treatment for thrombotic events.


Licensing Contact

Mike Villalobos
mike.villalobos@vanderbilt.edu
615.322.6751
Therapeutics
Cardiovascular

A Robotic System for Treating Intracranial Hemorrhage (ICH)

Vanderbilt researchers have designed a general purpose system for precise steering of multi-lumen needles. One significant application of the system is decompression of the cranium during hemorrhagic events (ICH).


Licensing Contact

Chris Harris
chris.harris@vanderbilt.edu
615.343.4433

Endonasal Surgical Robot for Sinus and Neurosurgery

Vanderbilt engineers have developed a robotic system for performing sinus and neurosurgery through the nose. This provides a less invasive way to access surgical sites in the sinuses and near the middle of the patient's head, leading to faster recovery times. The robot is modular and sterilizable with detachable cartridge-based instruments. Each instrument is a concentric tube robot, which is a needle-sized tool that can bend and elongate. The system delivers four of these instruments through a single nostril.


Licensing Contact

Chris Harris
chris.harris@vanderbilt.edu
615.343.4433

Transoral Lung Access Device

Transoral lung access is preferable to traditional needlebasedaccess due to the lower risk of lung collapse. However present bronchoscope-based devices enable access to only a small portion of the lung. The present device is a robotic image-guided bronchoscope to navigate the airway under closed-loop control to the target. IT is designed to provide transoral access to any location in the lung, particularly the hard-to-reach peripheral regions.


Licensing Contact

Chris Harris
chris.harris@vanderbilt.edu
615.343.4433
Medical Devices

Gratings on Porous Silicon Structures for Sensing Applications

In this technology diffraction-based sensors made from porous materials are used for the detection of small molecules. The porous nature of the diffraction gratings that gives rise to an extremely large active sensing area enables a very high level of sensitivity. Specificity is achieved by functionalizing the porous gratings with selective binding species.


Licensing Contact

Chris Harris
chris.harris@vanderbilt.edu
615.343.4433

Wolbachia genetic tools for population control of harmful insects

Vanderbilt scientists have engineered transgenic methods for controlling the populations of insects, including infectious disease vectors like mosquitoes and agricultural pests that destroy crops and livestock.


Licensing Contact

Cameron Sargent
cameron.sargent@vanderbilt.edu
615.322.5907

IntelliCane: Instrumented cane for diagnosis and evaluation of gait behavior in individuals with mobility issues.

This device is designed to assist physical therapists in collection of objective data during gait analysis, to facilitate appropriate assistive gait device prescription, to provide patients and therapists feedback during gait training, and to reduce wrist and shoulder injuries with cane usage.Currently gait characteristics are "measured" in a clinic-based atmosphere. This has two limitations: (i) subjective allocation of "measures" of gait characteristics and (ii) limited data based on trials in the clinic ONLY. What this technology is designed to do is achieve freedom from both of these limitations. The measurements are objective and numerical values (force etc.) and the clinic could provide the cane to the user for obtaining a much more extensive data set including use during normal life activities at home etc.


Licensing Contact

Masood Machingal
masood.machingal@vanderbilt.edu
615.343.3548
Medical Devices

I-Wire: A Biotension Measurement Device for Tissue Engineering and Pharmacology

Vanderbilt researchers have developed an integrated system ("I-Wire") for the growth of miniature, engineered 3D cardiac or other muscle or connective tissues and their active and passive mechanical characterization. The system utilizes an inverted microscope to measure the strain when the tissue constructs are laterally displaced using a calibrated flexible cantilevered probe.


Licensing Contact

Masood Machingal
masood.machingal@vanderbilt.edu
615.343.3548